Injection Trends 2025: Polynucleotides, Exosomes, Next-Generation Threads and Collagen Stimulators. Expert Insights from Dr. Mikhail Kordas
Dr. Mikhail Kordas, MD, Chief Physician of Lux Medicus aesthetic medicine clinics in Estonia and Finland, shares his expert view on the key injection trends shaping aesthetic medicine in 2025.
Aesthetic medicine is evolving rapidly. Just a few years ago, patients associated injections mainly with Botox or fillers. Today, increasing attention is given to procedures that not only correct appearance but also activate the skin’s natural regeneration and restoration processes.
Polynucleotides: a cellular boost for the skin
Polynucleotides stimulate regeneration and improve the overall quality of the skin.
• Increase elasticity and firmness.
• Hydrate and strengthen the skin.
• Reduce signs of photoaging.
“Polynucleotides work from the inside out — not to mask, but to improve the biology of the skin,” says Dr. Kordas.
Exosomes: a new level of regeneration
Exosomes are nanostructures that enable communication between cells and trigger tissue repair.
• Reduce inflammation.
• Stimulate collagen and elastin production.
• Make the skin firmer, healthier, and more radiant.
“Exosomes are a breakthrough that paves the way for future cellular technologies,” emphasizes the expert.
Next-generation collagen stimulators
Modern collagen stimulators act more gently and physiologically compared to earlier formulas.
• Provide gradual and natural rejuvenation.
• Help restore facial contours and strengthen tissues.
• Deliver long-lasting results.
“For patients over 35–40, collagen stimulators are becoming a key part of anti-age strategies,” adds Dr. Kordas.
Threads: mechanics and biology
Threads today are no longer just about mechanical lifting. With new materials, they also stimulate the body’s own collagen production.
• Strengthen tissues.
• Create a lifting effect without surgery.
• Ensure durable results.
Conclusion: the new face of injection medicine
The injection trends of 2025 prove that the modern approach is not “fill and mask,” but rather regeneration, natural results, and intelligent protocols.
“I view these methods as medical biohacking. The goal is not artificial change, but activating the body’s own restorative processes. In Estonia and Finland, patients value naturalness — and that defines the future of aesthetic medicine,” concludes Dr. Mikhail Kordas, MD, Chief Physician of Lux Medicus aesthetic medicine clinics in Estonia and Finland.


